Table 2.

Summary of the efficacy and safety assessments (open-label studies).

Study	Target	Efficacy assessments			Safety assessments
		Response rate	Remission rate	Recurrence rate	AEs	Suicide	Suicidal attempt
Mayberg et al. (2005), Torres (2008)	SCG	66.7%	33.3%	-	50.0%	-	-
Lozano et al. (2008), Taghva et al. (2013)	SCG	55.0%	35.0%	10.0%	65.0%	-	-
Kennedy et al. (2011), Williams et al. (2016)	SCG	75.0%	50.0%	-	75.0%	2	2
Lozano et al. (2008), Holtzheimer et al. (2012)	SCG	91.7%	58.3%	17.6%	64.7%	-	4
Malone et al. (2009), Lozano et al. (2012)	SCG	61.9%	-	-	42.9%	1	1
Bewernick et al. (2010), Puigdemont et al. (2012)	SCG	62.5%	50.0%	40.0%	75.0%	-	1
Nahas et al. (2010), Merkl et al. (2013)	SCG	33.3%	33.3%	-	100.0%	-	-
Malone et al. (2009), Puigdemont et al. (2015)	VC/VS	40.0%	20.0%	-	40.0%	-	4
Sartorius et al. (2010), Dougherty et al. (2015)	VC/VS	23.3%	20.0%	-	73.3%	1	5
Nahas et al. (2010), Fenoy et al. (2016)	EpC	60.0%	60.0%	-	60.0%	-	-
Dougherty et al. (2015), Williams et al. (2016)	EpC	60.0%	60.0%	-	100.0%	-	4
Bewernick et al. (2010), Accolla et al. (2016)	Nac	50.0%	30.0%	-	-	1	1
Jiménez et al. (2005), Schlaepfer et al. (2013)	sMFB	85.7%	57.1%	-	71.4%	-	-
Schlaepfer et al. (2013), Fenoy et al. (2016)	sMFB	66.7%	66.7%	-	100.0%	-	-
Merkl et al. (2013), Accolla et al. (2016)	PGR	20.0%	20.0%	-	-	-	-
Kuo et al. (2014), Bergfeld et al. (2016)	vALIC	40.0%	20.0%	-	28.0%	1	6

AEs, Adverse Events; SCG, Subcallosal Cingulate Gyrus; VC/VS, Ventral Capsule/Ventral Striatum; NAc, Nucleus Accumbens; EpC, Epidural prefrontal Cortical; vALIC, Ventral Anterior Limb of the Interna Capsule; sMFB, Supero-lateral branch of the Medial Forebrain Bundle; PGR, Posterior Gyrus Rectus; -, Not Available.