Table 3.

Summary of the efficacy and safety assessments (randomized controlled studies).

Study	Target	Efficacy assessments			Safety assessments
		Response rate	Remission rate	Recurrence rate	AEs	Suicide	Suicidal attempt
Puigdemont et al. (2015), Mayberg et al. (2005)	SCG	Active: 80%Control: 40%	Active: 80% Control: 40%	Active: 0%Control: 40%	-	-	-
Sartorius et al. (2010), Dougherty et al. (2015)	VC/VS	Active: 20%Control: 14.2%	-	-	Active: 66.7% Control: 26.7%	-	2
Kuo et al. (2014), Bergfeld et al. (2016)	vALIC	-	-	-	-	1	6

AEs, Adverse Events; SCG, Subcallosal Cingulate Gyrus; VC/VS, Ventral Capsule/Ventral Striatum; vALIC, Ventral Anterior Limb of the Interna Capsule; -, Not Available.