Table 2.
Main MR results of the effect of Hcy on neurodegenerative disease.
| SNP | Nearby gene | MS† | AD | PD | ALS | FTD‡ | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | ||
| rs1801133 | MTHFR | NA | NA | 1.01 (0.98–1.04) | 0.352 | 1.01 (0.97–1.04) | 0.698 | 1.02 (0.99–1.05) | 0.123 | NA | NA |
| rs2275565 | MTR | 0.96 (0.92–1.00) | 0.059 | 1.00 (0.97–1.04) | 0.970 | 1.01 (0.97–1.05) | 0.591 | 0.98 (0.95–1.01) | 0.165 | NA | NA |
| rs9369898 | MUT | NA | NA | 1.02 (0.99–1.05) | 0.260 | 1.00 (0.96–1.03) | 0.882 | 1.00 (0.98–1.03) | 0.767 | 0.94 (0.82–1.08) | 0.356 |
| rs7130284 | NOX4 | 0.98 (0.92–1.04) | 0.528 | 0.97 (0.92–1.02) | 0.269 | 0.97 (0.89–1.06) | 0.511 | 0.96 (0.92–1.02) | 0.176 | 1.25 (0.96–1.64) | 0.099 |
| rs154657 | DPEP1 | 1.01 (0.98–1.04) | 0.616 | 1.01 (0.98–1.04) | 0.550 | 1.00 (0.97–1.04) | 0.987 | 1.02 (0.99–1.04) | 0.263 | 1.13 (0.99–1.29) | 0.080 |
| rs234709 | CBS | NA | NA | 1.00 (0.97–1.03) | 0.944 | 1.01 (0.97–1.05) | 0.730 | 1.00 (0.98–1.03) | 0.837 | NA | NA |
| rs4660306 | MMACHC | NA | NA | 1.01 (0.98–1.04) | 0.394 | 1.02 (0.98–1.06) | 0.253 | 1.02 (1.00–1.05) | 0.103 | 1.04 (0.90–1.20) | 0.588 |
| rs548987 | SLC17A3 | 1.04 (0.99–1.09) | 0.088 | 0.98 (0.94–1.02) | 0.325 | 1.01 (0.95–1.06) | 0.846 | 1.03 (0.99–1.07) | 0.212 | NA | NA |
| rs42648 | GTPB10 | NA | NA | 0.99 (0.96–1.02) | 0.390 | 0.98 (0.95–1.02) | 0.343 | 0.98 (0.95–1.00) | 0.087 | 1.03 (0.90–1.18) | 0.710 |
| rs1801222 | CUBN | NA | NA | 1.00 (0.97–1.03) | 0.895 | 1.01 (0.97–1.05) | 0.587 | 1.02 (0.99–1.05) | 0.183 | NA | NA |
| rs2251468 | HNF1A | 1.00 (0.96–1.03) | 0.870 | 1.01 (0.98–1.04) | 0.606 | 0.99 (0.96–1.02) | 0.526 | 0.98 (0.95–1.01) | 0.189 | NA | NA |
| rs838133 | FUT2 | NA | NA | 0.98 (0.95–1.01) | 0.196 | 1.02 (0.98–1.06) | 0.301 | 1.02 (0.99–1.05) | 0.266 | NA | NA |
| rs12780845 | CUBN | 1.02 (0.98–1.05) | 0.303 | 0.99 (0.96–1.02) | 0.377 | 0.99 (0.96–1.03) | 0.765 | 1.01 (0.98–1.04) | 0.616 | 1.04 (0.90–1.20) | 0.595 |
SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidential interval; MS, multiple sclerosis; AD, Alzheimer’s disease; PD, Parkinson’s disease; ALS, amyotrophic lateral sclerosis; FTD, frontotemporal dementia; NA, not applicable.
†
Included SNPs: rs2275565 (proxy: rs10158822), rs7130284 (proxy: rs11018628), rs154657 (proxy: rs460879), rs548987 (proxy: rs501220), rs2251468 (proxy: rs2244608), and rs12780845 (proxy: rs10490958).
‡
Included SNPs: rs9369898 (proxy: rs2501968), rs7130284 (proxy: rs10501705), rs154657 (proxy: rs460879), rs4660306 (proxy: rs2991966), rs42648 (proxy: rs42659), and rs12780845 (proxy: rs7095324).