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. 2021 Apr 1;9:657337. doi: 10.3389/fcell.2021.657337

FIGURE 1.

FIGURE 1

SOCE regulates neural stem cell physiology. Store-operated Ca2+ entry (SOCE) and its molecular components positively regulate the proliferation of embryonic stem cells (ESCs) and neural stem cell (NSCs)/neural progenitor cells (NPCs), differentiation of ECSs, and NSCs/NPCs as well as neurogenesis. References that correspond to respective discoveries are shown in the figure. The upward arrows indicate that SOCE and its molecular players positively regulate proliferation, differentiation, and neurogenesis. Compared with other studies Gopurappilly et al. (2018) (reference indicated in the figure by a down arrow) detected a decrease in NSC differentiation.