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. 2021 Apr 1;9:659177. doi: 10.3389/fcell.2021.659177

FIGURE 2.

FIGURE 2

Effect of DaH, ZK, and CQZ treatment on DMD cardiomyocyte function. (A) Representative image of micropatterned hiPSC-CMs, showing single cell with aligned sarcomere. (B) Representative motion tracing of single wild type (WT) hiPSC-CMs and DMD hiPSC-CMs. (C) Beating rate and (D) contraction velocity of single DMD hiPSC-CMs treated with YXC, DaH, ZK, CQZ, or Vehicle (n = 8). ###P < 0.001 versus WT; *P < 0.05, **P < 0.01, and ***P < 0.001 versus vehicle. (E) Representative extracellular field potential (EFP) traces and (F) quantification of monolayer DMD hiPSC-CMs treated with YXC, DaH, ZK, CQZ, or Vehicle. WT hiPSC-CMs served as healthy control (n = 12). ###P < 0.001 versus WT; *P < 0.05, **P < 0.01, and ***P < 0.001 versus vehicle; ns = no statistical significance.