FIGURE 6.

Active compounds from DaH, ZK, and CQZ increased DMD hiPSC-CMs contractility and mitochondrial respiration. (A) Representative impedance (IMP) traces of monolayer DMD hiPSC-CMs treated with active compounds or vehicle. (B) Quantification of the IMP and (C) beating rate of monolayer DMD hiPSC-CMs treated with active compounds or vehicle. WT hiPSC-CMs served as healthy control. (D) Real-time mitochondrial respiration measurements of hiPSC-CMs. (E) Quantification of basal mitochondrial respiration and (F) maximal respiration of WT and DMD hiPSC-CMs treated with active compounds or vehicle (n = 5). ^#P < 0.05 versus WT; ^###P < 0.001 versus WT; *P < 0.05, **P < 0.01, and ***P < 0.001 versus vehicle; ns = no statistical significance.