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. 2021 Apr 1;9:636553. doi: 10.3389/fcell.2021.636553

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Copyright © 2021 Tian and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypoxic injury-induced oxidative modification of sarco/endoplasmic reticulum CSERCA2a and SERCA2a-induced Ca²⁺ imbalance (n = 3/group). (A,B) A calcium map was used to quantitatively analyze the change in [Ca²⁺]c (cytoplasmic calcium) in the different groups. (C–E) TUNEL assays and DCFH-DA fluorescence were used to assess cell survival. (F–I) ELISA results showing the changes in MDA, GPX, and SOD levels and the activity of SERCA2a after hypoxic injury in CMECs. (J–M) The relative expression levels of SERCA2a with nitrotyrosine and SERCA2a with sulfonylated cysteine were assessed by coimmunoprecipitation assays. *p < 0.05 compared with the Ad-Ctrl; ^#p < 0.05 compared with the Hypo(Ad-Ctrl).