Table 3.
Results of lung histological examination, molecular tissue and cultural analyses.
| ID | Histological findings | Molecular tests | Pathological diagnosis | ||
|---|---|---|---|---|---|
| COVID-19 related lesions* | Other lesions | Tissue real time RT-PCR | Culture | ||
| 1 | Diffuse alveolar damage/organizing pneumonia and vascular injury | + | + | Definite | |
| 2 | Diffuse alveolar damage/organizing pneumonia and vascular injury | + | Na | Definite | |
| 3 | Diffuse alveolar damage/organizing pneumonia and vascular injury | + | + | Definite | |
| 4 | No lesions | Iatrogenic paracetamol injury | – | Na | Other |
| 5 | Diffuse alveolar damage/organizing pneumonia | + | + | Definite | |
| 6 | Diffuse alveolar damage/organizing pneumonia | + | + | Definite | |
| 7 | Multiple foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Bronchial squamous cell carcinoma | + | + | Probable |
| 8 | Diffuse alveolar damage/organizing pneumonia | + | Na | Definite | |
| 9 | Multiple foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Bacterial pneumonia | – | Na | Probable |
| 10 | No lesions | Bacterial pneumonia | + | Na | Other |
| 11 | Diffuse alveolar damage/organizing pneumonia and vascular injury | + | Na | Definite | |
| 12 | Foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Diffuse squamous cell carcinoma | + | Na | Possible |
| 13 | Diffuse alveolar damage/organizing pneumonia and vascular injury | + | Na | Definite | |
| 14 | Multiple foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Bacterial pneumonia | + | + | Probable |
| 15 | Foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Malignant pleural solitary fibrous tumor | + | – | Possible |
| 16 | Multiple foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Aspergillus invasive bronchopneumonia | + | + | Probable |
| 17 | Multiple foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Bacterial pneumonia | + | – | Probable |
| 18 | Diffuse alveolar damage/organizing pneumonia and vascular injury | + | – | Definite | |
| 19 | No lesions | Aspiration/bacterial pneumonia | – | – | Other |
| 20 | Multiple foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Necrotizing granulomas | + | + | Probable |
| 21 | Diffuse alveolar damage/organizing pneumonia | + | – | Definite | |
| 22 | Multiple foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Aspiration pneumonia | + | + | Probable |
| 23 | Multiple foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Bacterial pneumonia | + | – | Probable |
| 24 | Foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Bacterial pneumonia | + | – | Possible |
| 25 | Diffuse alveolar damage/organizing pneumonia and vascular injury | + | – | Definite | |
| 26 | Diffuse alveolar damage/organizing pneumonia and vascular injury | + | + | Definite | |
| 27 | Multiple foci of diffuse alveolar damage/organizing pneumonia and vascular injury | Breast cancer metastases/bacterial pneumonia | + | – | Probable |
RT, reverse transcriptase; PCR, polymerase chain reaction; na: not available.
*
List of the most common histological findings detected. Diffuse alveolar damage/organizing pneumonia: hyaline membrane, edema, and hemorrhage (acute exudative phase); type 2 pneumocyte hyperplasia, organizing pneumonia, and squamous metaplasia (organizing/proliferative phase). Vascular injury: capillary inflammation, neutrophilic capillaritis, microthrombi and macrothrombi.