Table 2.
Multiple-SNV adjusted model for SNVs significantly associated with renal dysfunctiona 1-year post-transplant.
| Gene name | rs number | Chromosome | Allelesb | MAF (%) | Reference group | Adjustedc odds ratio (95% CI) | Adjustedc value of p |
|---|---|---|---|---|---|---|---|
| TGFB1 | rs4803455 | 19 | C > A | 45 | C/C | 0.28 (0.12–0.62) | 0.002 |
| PLCB1 | rs170549 | 20 | G > A | 28 | G/G | 2.66 (1.21–5.84) | 0.015 |
MAF, minor allele frequency; PLCB1, phospholipase C beta 1; SNV, single nucleotide variant; and TGFB1, transforming growth factor beta 1.
a
Defined as an eGFR <45 ml/min/1.73m2.
b
Major > minor alleles, respectively.
c
Model adjusting for pre-transplant renal dysfunction, age at transplant, cyclosporine use at 1-year post-transplant, transplant era, and the top four principal components (PCs).