Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 1;9:627153. doi: 10.3389/fcell.2021.627153

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Madel, Fu, Pierroz, Schiffrin, Winkler, Wilson, Pochon, Toffoli, Taïeb, Jouzeau, Gilardi, Ferrari, Bonnet, Blin-Wakkach, Desvergne and Moulin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Epiblastic PPARγ-deletion induces trabecular and cortical bone alteration. (A) Micro-CT analysis of femur from Pparg^Δ/Δ (γ^Δ/Δ) one-year old female mice or control female littermates (CTL). Dot plots on the right show for the different genotypes (empty square for CTL and black triangle for γ^Δ/Δ) the percentage bone volume/trabecular volume (BV/TV) in % and connectivity density (ConnDens) of distal femoral trabecular bone (upper panels), and the cortical bone volume (BV) in mm³ and the percentage of cortical porosity of femur (lower panels). All mice were 1-year-old. (B) RT-qPCR analysis of Alkaline phosphatase (AlpI) gene expression in femur from CTL and γ^Δ/Δ. (C) ELISA measurements of serum Alkaline phosphatase (ALP) and osteocalcin (OCN). (D) RT-qPCR analysis of Acid Phosphatase 5-Tartrate Resistant (Acp5), Cathepsin K (Ctsk), and Matrix Metallopeptidase 9 (Mmp9) expression in femur from CTL and γ^Δ/Δ. (E) ELISA measurements of serum Carboxy-terminal Collagen I telopeptide (CTX). (F) Representative images of TRAcP staining of decalcified sections of femurs, at mid-shaft levels, from control (CTL) or Pparg^Δ/Δ (γ^Δ/Δ) mice. CB, cortical bone; BM, bone marrow. Data are presented as mean ± S.E.M. Each dot represents an individual animal. Statistical significance was determined by two-tailed unpaired t-test.