TABLE 1.
(A) Micro-CT data were obtained from variousbones in Ppargfl/+ and PpargΔ/Δ of 1 year-old female mice. (B) Similar evaluation of bones from 5/6 month-old female mice.
|
A. Micro CT analyses of 1 year-old femalemice | ||
| 1 year | Ppargfl/+ | PpargΔ/Δ |
| No. of animals assessed | 15 | 14 |
| Cortical TV (mm3) | 1.4980.023 | 1.3270.031* |
| Cortical BV (mm3) | 0.7230.012 | 0.6670.028* |
| Cortical thickness (μm) | 241.84.5 | 208.010.4* |
| Dist femoral BV/TV (%) | 3.410.49 | 14.382.26* |
| Dist femoral conn density (mm3) | 9.182.57 | 81.8913.62* |
| Dist femoral Tb N (/mm) | 2.390.09 | 3.610.22* |
| Dist femoral Tb Th (μm) | 54.372.48 | 57.283.52* |
| Dist femoral Tb Sp (μm) | 431.3418.4 | 291.109.70* |
| Vertebral BV/TV (%) | 17.331.38 | 29.573.30* |
| Vertebral conn density (mm3) | 127.0214.89 | 519.4473.33* |
| Vertebral Tb N (/mm) | 3.420.17 | 6.290.53* |
| Vertebral Tb Th (μm) | 51.431.88 | 47.042.30 |
| Vertebral Tb Sp (μm) | 311.1316.23 | 177.3015.73* |
| B. Complete bone analysis by micro CT of 5/6 month-old female mice | ||
| 5–6 months | Ppargfl/+ | PpargΔ/Δ |
| No. of animals assessed | 8 | 10 |
| Cortical TV (mm3) | 1.180.05 | 1.180.04 |
| Cortical BV (mm3) | 0.05410.023 | 0.05480.014 |
| Cortical thickness (μm) | 203.754.80 | 202.805.33 |
| Dist femoral BV/TV (%) | 7.781.17 | 8.551.07 |
| Dist femoral conn density (mm3) | 38.908.70 | 84.3014.85* |
| Dist femoral Tb N (/mm) | 3.130.13 | 3.750.22* |
| Dist femoral Tb Th (μm) | 53.011.62 | 45.932.24* |
| Dist femoral Tb Sp (μm) | 327.4615.03 | 283.5921.33 |
| Vertebral BV/TV (%) | 15.491.31 | 21.441.79* |
| Vertebral conn density (mm3) | 112.7312.56 | 275.5333.10* |
| Vertebral Tb N (/mm) | 3.710.13 | 4.760.17* |
| Vertebral Tb Th (μm) | 49.031.17 | 46.391.14 |
| Vertebral Tb Sp (μm) | 278.3710.66 | 215.18.32* |
Values are given as mean ± standard deviation. TV, total volume; BV, bone volume; Tb N, trabecular number; Tb Th, trabecular thickness; Tb Sp, trabecular separation. ∗p <0.05 vs. Ppargfl/+.