Reagent or resource	Source	Identifier
Antibodies
Neutralizing adiponectin receptor 1 polyclonal antibody	Enzo life science	ALX-210- 645-C200
Adiponectin rabbit monoclonal antibody	Cell signaling technology	#2789
AMPK(Rabbit mAb (D63G4)	Cell signaling technology	#5832
Phospho-AMPKα (Thr172) (40H9) Rabbit mAb	Cell signaling technology	#2535
Chemicals, peptides, and recombinant proteins
Fetal Bovine Serum	GIBCO	10082139
Alpha MEM with NTP, dNTP	GIBCO	22571
AdipoRon	SIGMA	SML0998
mRANKL	R&D systems	462-TEC
hRANKL	R&D systems	6449-TEC
Critical commercial assays
Acid Phosphatase, Leukocyte (TRAP) assay	SIGMA	387A
murine serum CTX ELISA	LSBio	F21349
murine serum OCN ELISA	LSBio	F12227
murine serum PTH ELISA	LSBio	F23085
Experimental models: cell lines
3T3-L1 pre adipose murine cell line	ATCC	CL-173
RAW 264.7 murine macrophage	ATCC	TIB-71
Experimental models: organisms/strains
Sox2-Cre mouse	The Jackson Laboratory	004783
Adipoq-Cre mouse	The Jackson Laboratory	010803
Pparγ L2/L2 mouse	B Desvergne
AZIP/F1 tg mouse	C Vinson
Oligonucleotides (primers): see Supplementary Table 1
Software and algorithms
CTan CTVol	Skyscan
ImageJ	Fiji