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. 2021 Apr 1;9:650666. doi: 10.3389/fcell.2021.650666

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Copyright © 2021 Wang, Xu, Zhang, Fang, Yang, Zeng, Wei, Liu, Zhou, Li, Huang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knocking out miR-22 reduces the apoptotic index of the myocardium after CLP and alleviates myocardial injury. (A) Representative images of TUNEL staining (myocardium); Scale bar = 50 μm. (B) Percentage of TUNEL-positive nuclei. (C) Representative Western blots. (D) Relative cleaved-caspase9 protein level ratio. (E) Relative cleaved-caspase3 protein level ratio. (F) Relative BAX protein level ratio. (G) Relative Bcl-2 protein level ratio. Data were expressed as mean ± SEM. ^∗P < 0.05 vs. sham group; ^‡P < 0.05 vs. CLP group; ^†P < 0.05 vs. miR-22^cKO sham group. (G) Representative images of TUNEL staining; Scale bar = 25 μm; (H) Percentage of TUNEL-positive nuclei. ^∗P < 0.05 vs. NC group; ^‡P < 0.05 vs. NC + LPS group; ^†P < 0.05 vs. miR-22 inhibitor group. All the experiments were repeated three times.