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The m6A modification of NRIP1 transcripts decreased in DS cerebral cortex. (A) RNA-seq data showed that NRIP1 mRNA was significantly upregulated in DS compared with control. (B) RT-qPCR analysis confirmed that NRIP1 mRNA was increased in DS tissue. (C,D) NRIP1 protein level analyzed by western blotting in DS and control fetal cerebral cortex tissues. (E) The abundance of m6A modified NRIP1 mRNA was reduced in DS cerebral cortex compared with control sample.
