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. 2021 Apr 1;11:579286. doi: 10.3389/fonc.2021.579286

Figure 1.

Figure 1

An overview of ferroptosis. ARE, antioxidant response element; BSO, buthionine sulfoximine; CoQ10, coenzyme Q10; CUL3, cullin3; DFO, deferoxamine; DFOM, desferrioxamine mesylate; DMT1, divalent metal transporter 1; FPN, ferroportin; FSP1, ferroptosis suppressor protein 1; GCL, glutamate-cysteine ligase; GLS2, glutaminase 2; GPX4, GSH peroxidase 4; GSH, glutathione; GSS, glutathione synthetase; 4-HNE, 4-hydroxynonenal; HO•, hydroxyl radical; IKE, imidazole ketone erastin; KEAP1, Kelch-like ECH-associated protein 1; LIP, labile iron pool; LOX, lipoxygenase; MDA, malondialdehyde; MSRB2, methionine-R-sulfide reductase B2; NCOA4, nuclear receptor coactivator 4; NRF2, nuclear factor erythroid 2-related factor 2; PE, piperazine erastin; PL, phospholipid; PL•, PL radical species; PLO•, PL alkoxyl radical; PLOH, PL alcohol; PLOO•, PL peroxyl radical; PLOOH, PL hydroperoxide; RBX1, ring box protein 1; RSL3, RAS synthetic lethal 3; SAS, sulfasalazine; SCARA5, scavenger receptor class A member 5; sMAF, small Maf; SLC1A5, solute carrier family member 1 member A5; STEAP, six-transmembrane epithelial antigen of prostate; TFR1, transferrin receptor 1; ZIP8, Zrt- and Irt-like protein 8.