Table 1.

Regulators of ferroptosis.

Gene	Protein	Effect	References
Amino acid and GSH metabolism
GCL	Glutamate-cysteine ligase	Inhibition induces ferroptosis	42
G6PD	Glucose-6-phosphate dehydrogenase	Knockdown hinders erastin-induced ferroptosis	3
PGD	Phosphoglycerate dehydrogenase	Knockdown hinders erastin-induced ferroptosis	3
SLC7A11	Solute carrier family 7 member A11, xCT	Inhibition induces ferroptosis	3
		Knockout hinders erastin-induced ferroptosis	43
GLS2	Glutaminase 2	Upregulation induces p53-dependent ferroptosis	44
GOT1	Glutamic-oxaloacetic transaminase 1	Modulates ferroptosis in the mitochondrial tricarboxylic acid cycle	45
Iron metabolism
TFR1	Transferrin receptor 1	Knockdown suppresses ferroptosis	46
DMT1	Divalent metal transporter 1	Upregulation promotes SAS-induced ferroptosis	47
NCOA4	Nuclear receptor coactivator 4	Knockdown suppresses ferroptosis induced by amino acid/cystine deprivation	48
FPN	Ferroportin	Downregulation in ferroptosis	49
Lipid metabolism
ACSL4	Acyl-CoA synthetase long-chain family member 4	Inhibition or knockout suppresses ferroptosis	50; 51
LPCAT3	Lysophosphatidylcholine acyltransferase 3	Inhibition or knockout suppresses ferroptosis	50; 51
LOX	Lipoxygenase	Promotes ferroptosis	4
Key regulators
GPX4	GSH peroxidase 4	Inhibition induces ferroptosis	52
FSP1	Ferroptosis suppressor protein 1	Induces ferroptosis resistance	53; 54
NFE2L2	Nuclear factor erythroid 2-related factor 2	Inhibition could reverse the resistance of cisplatin-resistant HNC cells to artesunate-induced ferroptosis	55
TP53	p53	Promotes ferroptosis	56; 57
		Suppresses ferroptosis	58