Table 2.
Inducers and inhibitors of ferroptosis in different cancers.
| Cancer | Inducer | Reference | Inhibitor | Reference |
|---|---|---|---|---|
| Hepatocellular carcinoma | Auranofin BSO Haloperidol Rb miRNA-214-3p |
160; 161; 162; 163 |
Ceruloplasmin S1R CISD1 CBS O-GlcNAcylated c-Jun lncRNA GABPB1-AS1 |
164; 165; 166; 83; 167; 168 |
| Pancreatic cancer | Artesunate Ruscogenin ARF6 Piperlongumine STAT3 |
169; 170; 49; 171; 172 |
LONP1 KRASG12D GPR78 |
173; 174; 175 |
| Glioma | Dihydroartemisinin Amentoflavone Pseudolaric acid B |
176; 177; 178 |
HSPA5 GDF15 circRNA TTBK2 |
176; 179; 180 |
| Lung cancer | Acetaminophen Erianin |
181; 145 |
NFS1 STYK1 EGLN1/c-Myc lncRNA LINC00336 |
182; 183; 184; 185 |
| Breast cancer | SAS Siramesine Lapatinib Dihydroisotanshinone I Ferroptocide |
186; 187; 188; 47 |
– | – |
| Head and neck cancer | RSL3 ML-162 Dihydroartemisinin |
189; 132 |
SLC7A11 CISD2 |
190; 68 |
| Colorectal cancer | RSL3 Bromelain Birch Etna Vitamin C |
191; 192; 52 |
– | – |
| Gastric cancer | ACP PG |
193; 194 |
miRNA-522 miRNA-103a-3p circRNA 0008035 |
195; 196; 194 |
| Melanoma | miRNA-9 | 197 | AKR1C1-3 Nedd4 miRNA-137, |
139; 198; 199 |
| Leukemia | Dihydroartemisinin Typhaneoside HMGB1 |
200; 201; 202 |
– | – |
| Ovarian cancer | TAZ | 203 | SCD1 CBS |
204; 205 |
| Renal cell carcinoma | HIF-2α TAZ MAPK |
206; 207; 208 |
VHL | 209 |
| Lymphoma | Artesunate | 210 | – | – |
| Osteosarcoma | Phenethyl isothiocyanate | 211 | – | – |
| Esophageal cancer | DNAJB6 | 212 | – | – |
ACP, Actinidia chinensis Planch; AKR1-3, aldo-keto reductase 1-3; ARF6, ADP-ribosylation factor 6; BSO, buthionine sulfoximine; CBS, cystathionine β-synthase; CDO1, cysteine dioxygenase 1; CISD1, CDGSH iron sulfur domain 1; DNAJB6, DNAJ/Hsp40 homolog subfamily B member 6; GDF15, growth/differentiation factor 15; GPR78, glucose-regulated protein 78; HIF-2α, hypoxia inducible factor 2α; HMGB1, high mobility group box 1; HSPA5, heat shock protein family A member 5; IKE, imidazole ketone erastin; LONP1, lon peptidase 1; MAPK, mitogen-activated protein kinase; NFS1, human mitochondrial cysteine desulfurase; PG, physcion 8-O-β-glucopyranoside; Rb, retinoblastoma; S1R, Sigma-1 receptor; SAS, sulfasalazine; SCD1, steroyl-CoA desaturase 1; SLC7A11, solute carrier family 7 member A11; STAT3, signal transducer and activator of transcription 3; STYK1, serine threonine tyrosine kinase 1; TAZ, transcription regulator 1; VHL, vov Hippel-Lindau.