Table 1.

Histopathological abnormalities observed in an experimental ferret model.

References	Date	Main specific immunohistopathological findings
Kim et al. (2020)	4 days post-infection	- Increased immune infiltration and cell debris in the alveolar wall, bronchial epithelium, and bronchial lumen, suggestive of acute bronchiolitis
	12 days post-infection	- Disappearance of pathological abnormalities
Ryan et al. (2021)	3–14 days post-infection	- Mild multifocal bronchopneumonia - Mild necrosis of the bronchiolar epithelial cells together with inflammatory cell infiltration of neutrophils and mononuclear cells within the bronchiolar lumina
Shi et al. (2020)	13 days post-infection	- Severe lymphoplasmacytic perivasculitis and vasculitis in lungs - Increased numbers of type II pneumocytes, macrophages and neutrophils in the alveolar septa and alveolar lumen - Mild peribronchitis