Table 3.
MiRNAs that modulate chemoresistance through apoptosis related proteins in OC.
| miRNAs | Cell/tissue | Chemotherapy | Target mRNA | Response to treatment | References |
|---|---|---|---|---|---|
| BCL-2 family members | |||||
| miR-137 | OVCAR3 | Cisplatin | MCL1 | ↑ | (36) |
| miR-17~92 cluster | A2780, OVCAR3, SKOV3 | Cisplatin | BCL2 | ↑ | (37) |
| miR−335- 5p | A2780, OVCAR3, OV90 | Cisplatin | BCL2L2 | ↑ | (38) |
| miR−146a−5p | OVCAR3, SKOV3 | Cisplatin | BCL2L2, XIAP, BIRC2, BIRC5 |
↑ | (39) |
| miR-509-3p | OVCAR3, SKOV3 | Cisplatin | BCL2, BCL2L2, MCL1 |
↑ | (40) |
| miR-125b | OV2008, C13* | Cisplatin | Bak1 | ↓ | (41) |
| XIAP | |||||
| miR-137 | A2780, SKOV3 | Cisplatin | XIAP | ↑ | (42) |
| miR-130a | A2780 | Cisplatin | XIAP | ↑ | (43) |
| miR-519d | A2780, OVCAR3, SKOV3 | Cisplatin | XIAP | ↑ | (44) |
| miR-149 | SKOV−3, HO8910, ES2 | Cisplatin | XIAP | ↑ | (45) |
| miR-142-5p | OVCAR3, SKOV3 | Cisplatin | XIAP | ↑ | (46) |
| P53 | |||||
| let-7d-5p | A2780, OVCAR3, SKOV3 | Cisplatin | HMGA1 | ↑ | (47) |