Table 4.
Inactivation of apoptosis related pathway and miRNAs in OC.
| miRNAs | Cell/tissue | Chemotherapy | Target mRNA | Response to treatment | Reference |
|---|---|---|---|---|---|
| PI3K/Akt pathway | |||||
| miR-221/222 | A2780 | Cisplatin | PTEN | ↓ | (48) |
| miR-216a | OVCA433, SKOV3 | Cisplatin | PTEN | ↓ | (49) |
| miR-186 | A2780, SKOV3 | Cisplatin | PTEN, APAF1 | ↑ | (50) |
| miR-186 | A2780, SKOV3 | Cisplatin | PIK3R3 | ↓ | (50) |
| miR-34c | A2780, SKOV3 | Cisplatin | MET | ↑ | (51) |
| miR-124-3p.1 | A2780, SKOV3 | Carboplatin | CAV1 | ↑ | (52) |
| miR-503 | SKOV3 | Cisplatin | PI3K, p85 | ↑ | (53) |
| MAPK pathway | |||||
| miR-330-5p | Caov3, SKOV3 | Cisplatin | S100A7 | ↑ | (54) |
| miR-634 | A2780, OV56, OAW42 | Cisplatin | Ras-MAPK pathway | ↑ | (55) |
| miR-21 | SKOV3ip1, HEYA8, A2780, CP20 | Cisplatin | JNK-1/c-Jun | ↓ | (56) |