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. 2021 Apr 1;12:636775. doi: 10.3389/fimmu.2021.636775

Table 1.

Summary of humanized mouse models and their tissue-based chimerism.

SCID-hu hu-PBL hu-HSC BLT TKO-BLT
Mouse Model graphic file with name fimmu-12-636775-i001.jpg graphic file with name fimmu-12-636775-i001.jpg graphic file with name fimmu-12-636775-i001.jpg graphic file with name fimmu-12-636775-i001.jpg graphic file with name fimmu-12-636775-i002.jpg
Genetic Background C.B17scid/scid
(SCID)		 SCID
NOD-SCID
NSG
BRG
NCG		 SCID
NOD-SCID
NSG
BRG
NRG
DRAG		 SCID
NOD-SCID
NSG
NRG		 C57BL/6 Rag2 -/-
gc-/-
Humanization Method Subcapsular Coimplantation of human fetal thymus and liver fragments Intraperitoneal Injection of human PBMCs Injection of CD34+ cells from cord blood/fetal liver Coimplantation human fetal thy/liv with i.v. injection of CD34+ cells from fetal liver Coimplantation human fetal thy/liv with i.v. injection of CD34+ cells from fetal liver
graphic file with name fimmu-12-636775-i003.jpg graphic file with name fimmu-12-636775-i004.jpg graphic file with name fimmu-12-636775-i005.jpg graphic file with name fimmu-12-636775-i006.jpg graphic file with name fimmu-12-636775-i006.jpg
Immune Reconstitution T cell engraftment
Multilineage hematopoiesis
No primary immune response		 T cell engraftment
No multilineage hematopoiesis
No primary immune response		 Multilineage hematopoiesis
Primary immune response
No HLA restriction		 Multilineage hematopoiesis
Primary immune response
Human HLA T cell restriction		 Multilineage hematopoiesis
Primary immune response
Human HLA T cell restriction
References McCune Namikawa (11), Namikawa Weilbaecher (12) Moiser, Gulizia (13), Hesselton. Greiner (14), van Rijn, Simonetti (15), Ali, Flutter (16) Kamei-Reid and Dick (17), Peault, Weissman (18), Hiramatsu, Nishikomori (19), Danner, Chaudhari (20) Lan, Tonomura (21), Melkus, Estes (22), Brainard, Seung (23), Stoddart, Maidji (24) Lavender, Messer (25), Lavender, Pang (26), Lavander, Pace (27)

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