Table 3.
Summary of therapeutic approaches and humanized mouse models utilized in their testing.
| Therapeutic approach | Model | Genetic background | References |
|---|---|---|---|
| bNAbs | Hu-PBL | SCID | Poignard, Sabbe (47) |
| Hu-HSC | NRG | Klein, Halper-Stromberg (48), Horwitz, Halper-Stromberg (49), Halper-Stromberg, Lu (50) | |
| NSG | Wang, Gajjar (51) | ||
| BLT | NSG | Badamchi-Zadeh, Tartaglia (52) | |
| CAR T Cell Therapy | Hu-HSC | SCID | Kitchen, Bennett (53) |
| BLT | NSG | Kitchen, Levin (54), Zhen, Kamata (55) | |
| Hu-PBL | NSG | Leibman, Richardson (56), Bardhi, Wu (57), Anthony-Gonda, Bardhi (58) | |
| Zinc Finger Nucleases | Hu-PBL | NOG | Perez, Wang (59) |
| NSG | Yi, Choi (60), Wilen, Wang (61), Yuan, Wang (62) | ||
| TALENs | Hu-HSC | NSG | Llewellyn, Seclén (63) |
| CRISPR/Cas9 | Hu-PBL | NCG | Xiao, Chen (64) |
| Hu-HSC | NSG | Dash, Kaminski (65) | |
| BLT | NSG | Yin, Zhang (66) | |
| Block and Lock | BLT | NSG | Kessing, Nixon (67) |