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. 2021 Apr 1;9:644954. doi: 10.3389/fcell.2021.644954

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Copyright © 2021 He, Lu, Guo, Li, Lu, Shao, Zhou, Wang, Wang, Gao and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deficiency of KLF15 aggravated Ang II-induced cardiac remodeling. Wild-type (WT) mice and KLF15 knockout (KO) mice were infused with saline or Ang II for 14 days. (A) Representative heart size, WGA stain, Masson stain, and α-SMA immunofluorescence image. (B) Statistical analysis of heart weight/body weight ratio. (C) Quantification analysis of myocyte section area. (D) Quantification analysis of fibrotic area measured by Masson stain. (E) Quantification analysis of α-SMA positive area measured by immunofluorescence. (F) Statistical analysis of blood pressure. (G–I) qPCR analysis of mRNA levels of ANP, BNP, Collagen 1a1, and CXCL1. *P < 0.05, **P < 0.01, and ***P < 0.001.