Table 3.
Logistic regression analysis to evaluate the association of fibrosis with clinical outcomes.
| Endotracheal intubation – demographic variables | ||||
|---|---|---|---|---|
| OR | CI 95% | β | p value | |
| Fibrosis APRI/NFS | 2.595 | 1.187 - 5.662 | 0.954 | 0.017 |
| Gender (Female) | 0.478 | 0.202 – 1.131 | -0.738 | 0.093 |
| Age | 0.980 | 0.969 – 0.991 | -0.020 | 0.001 |
| BMI > 30 kg/m2 | 0.788 | 0.409 – 1.519 | -0.238 | 0.477 |
| -2 log likelihood →block 0: 245.37, block 1:192.90; Cox & Snell R2: 0.257; Nagelkerke R2: 0.342; Hosmer and Lemeshow: 0.420 | ||||
| Endotracheal intubation – Biochemical variables | ||||
| OR | CI 95% | β | p value | |
| Fibrosis APRI/NFS | 2.869 | 1.181 – 6.970 | 1.054 | 0.020 |
| LDH | 1.000 | 0.997 – 1.002 | 0.001 | 0.889 |
| CRP | 1.038 | 0.993 – 1.086 | 0.038 | 0.099 |
| CPK | 1.000 | 0.999 – 1.001 | 0.000 | 0.514 |
| Total lymphocytes | 0.998 | 0.997 – 0.999 | -0.002 | 0.000 |
| -2 log likelihood →block 0: 227.35, block 1:195.675; Cox & Snell R2: 0.302; Nagelkerke R2: 0.402; Hosmer and Lemeshow: 0.202 | ||||
| Endotracheal intubation –Severity scores and markers | ||||
| OR | CI 95% | β | p value | |
| Fibrosis APRI/NFS | 2.601 | 1.112 – 6.084 | 0.956 | 0.027 |
| PSI/PORT score | 0.992 | 0.980 – 1.004 | -0.008 | 0.185 |
| qSOFA score | 3.288 | 1.380 – 7.836 | 1.190 | 0.007 |
| PaO2/FiO2 ratio | 0.992 | 0.989 - 0.995 | -0.008 | 0.000 |
| NLR | 1.003 | 0.973 – 1.035 | 0.003 | 0.827 |
| -2 log likelihood →block 0: 238.44, block 1:169.73; Cox & Snell R2: 0.329; Nagelkerke R2: 0.439; Hosmer and Lemeshow: 0.359 | ||||
| Endotracheal intubation – Combined model | ||||
| OR | CI 95% | β | p value | |
| Fibrosis APRI/NFS | 3.243 | 1.355 – 7.760 | 1.176 | 0.008 |
| Age | 0.974 | 0.953 - 0.995 | -0.026 | 0.017 |
| Total lymphocytes | 1.000 | 0.999 – 1.001 | 0.000 | 0.690 |
| qSOFA | 5.067 | 2.002 – 12.825 | 1.623 | 0.001 |
| PaO2/FiO2 ratio | 0.994 | 0.990 – 0.997 | -0.006 | 0.001 |
| -2 log likelihood →block 0: 239.82, block 1:163.66; Cox & Snell R2: 0.356; Nagelkerke R2: 0.475; Hosmer and Lemeshow: 0.154 | ||||
| Acute kidney injury - Demographic variables | ||||
| OR | CI 95% | β | p value | |
| Fibrosis APRI/NFS | 2.522 | 1.123 – 5.665 | 0.925 | 0.025 |
| Gender (Female) | 0.281 | 0.102 – 0.773 | -1.268 | 0.014 |
| Age | 0.982 | 0.971 – 0.994 | -0.018 | 0.002 |
| BMI > 30 kg/m2 | 0.622 | 0.314 – 1.231 | -0.476 | 0.173 |
| -2 log likelihood →block 0: 243.98, block 1:179.58; Cox & Snell R2: 0.307; Nagelkerke R2: 0.409; Hosmer and Lemeshow: 0.868 | ||||
| Acute kidney injury –Biochemical variables | ||||
| OR | CI 95% | β | p value | |
| Fibrosis APRI/NFS | 2.634 | 1.031 - 6.732 | 0.968 | 0.043 |
| LDH | 1.004 | 1.001 – 1.007 | 0.004 | 0.019 |
| CRP | 1.039 | 0.990 – 1.091 | 0.093 | 0.118 |
| CPK | 1.000 | 0.999 – 1.001 | 0.000 | 0.994 |
| Glucose | 1.002 | 0.997 – 1.007 | 0.002 | 0.413 |
| SBP | 0.967 | 0.955 – 0.980 | -0.033 | 0.000 |
| -2 log likelihood →block 0: 221.80, block 1: 138.47; Cox & Snell R2: 0.406; Nagelkerke R2: 0.541; Hosmer and Lemeshow: 0.176 | ||||
| Acute kidney injury - Severity scores and markers | ||||
| OR | CI 95% | β | p value | |
| Fibrosis APRI/NFS | 2.640 | 1.077 – 6.470 | 0.971 | 0.034 |
| SOFA | 1.169 | 0.949 – 1.440 | 0.156 | 0.143 |
| Bello-Chavolla score | 0.973 | 0.865 – 1.095 | -0.027 | 0.655 |
| PaO2/FiO2 ratio | 0.991 | 0.987 – 0.994 | -0.009 | 0.000 |
| NLR | 1.021 | 0.991 – 1.051 | 0.021 | 0.168 |
| -2 log likelihood →block 0: 232.89, block 1: 152.32; Cox & Snell R2: 0.381; Nagelkerke R2: 0.508; Hosmer and Lemeshow: 0.285 | ||||
| Acute kidney injury – Combined model | ||||
| OR | CI 95% | β | p value | |
| Fibrosis APRI/NFS | 2.511 | 1.000 – 6.304 | 0.921 | 0.050 |
| Gender | 0.397 | 0.130 – 1.206 | -0.925 | 0.103 |
| Age | 1.014 | 0.981 – 1.049 | 0.014 | 0.405 |
| PaO2/FiO2 ratio | 0.995 | 0.991 – 0.999 | 0.005 | 0.028 |
| LDH | 1.004 | 1.001 – 1.007 | 0.004 | 0.007 |
| SBP | 0.979 | 0.961 – 0.997 | 0.021 | 0.024 |
| -2 log likelihood →block 0: 230.12, block 1: 140.95; Cox & Snell R2: 0.416; Nagelkerke R2: 0.554; Hosmer and Lemeshow: 0.247 | ||||
APRI, AST to platelet ratio index; NAFLD fibrosis score; BMI, body mass index; LDH, lactate dehydrogenase; CRP, c-reactive protein; CPK, creatine phosphokinase; NLR, Neutrophil/Lymphocyte ratio, SBP, systolic blood pressure.