Table 4.

Cox regression analysis for survival in patients with and without fibrosis.

SURVIVAL – demographic variables
	HR	CI 95%	β	p value
Fibrosis APRI/NFS	2.332	1.077 – 5.049	0.847	0.032
Gender (Female)	0.424	0.154 – 1.171	-0.858	0.098
Age	1.035	1.002 – 1.070	0.035	0.040
BMI	1.087	1.029 – 1.147	0.083	0.003
-2 log likelihood →block 0: 245.43, block 1: 228.41, Chi-square:18.999, df:4, sig.: 0.001

Survival – severity scores and markers
	HR	CI 95%	β	p value
Fibrosis APRI/NFS	2.901	1.141 – 7.370	1.065	0.025
NLR	1.014	0.977 – 1.053	0.014	0.457
LDH	1.002	1.000 – 1.004	0.002	0.053
PSI-PORT	1.024	1.007 – 1.041	0.023	0.005
CRP	1.062	1.015– 1.111	0.060	0.010
qSOFA	0.693	0.254 – 1.890	-0.367	0.474
PaO2/FiO2 ratio	1.001	0.998 – 1.004	0.001	0.468
-2 log likelihood →block 218.91:, block 1:187.18, Chi-square:35.72, df:7, sig.:0.000

Survival – combined model
	HR	CI 95%	β	p value
Fibrosis APRI/NFS	2.543	1.147 - 5.637	0.933	0.022
PSI-PORT	1.017	1.000 - 1.034	0.017	0.050
CRP	1.070	1.025 - 1.118	0.068	0.002
Age	1.018	0.982 – 1.055	0.018	0.336
BMI	1.086	1.025-1.150	0.082	0.005
-2 log likelihood →block 0:235.13, block 1: 203.17, Chi-square:35.06, df:5, sig.: 0.000

Survival – other outcomes
	HR	CI 95%	β	p value
Fibrosis APRI/NFS	1.655	0.749 – 3.661	0.504	0.213
AKI	3.022	1.181 – 7.735	1.106	0.021
Endotracheal intubation	3.441	1.226 – 9.661	1.236	0.019
-2 log likelihood →block 247:, block 1: 181:, Chi-square:36.58, df:3, sig.:0.000

APRI, AST to platelet ratio index; NAFLD fibrosis score; BMI, body mass index; T2DM, type 2 diabetes mellitus; LDH, lactate dehydrogenase; AKI, acute kidney injury; CRP, C-reactive protein; NLR, neutrophil/lymphocyte ratio.