Figure 5.

The effect of shh on the progress of EAE. (A) Shh protein treatment was applied on the onset stage of EAE and the clinical score was observed across the progress of EAE. Data are shown as mean ± SEM. (B) LFB staining was used to study the demyelination of the spinal cord sections. The sections were obtained on the remission stage of EAE (images are representative of 4-5 mice in each group). The bar denotes 200 μm. Data (n = 3-5 mice in each group, and 5–6 sections from each mouse were used for LFB staining and scoring) are shown as mean ± SD. (*P < 0.05, ***P < 0.001).