Table 4.

Braak stages of Tau deposition (Braak and Braak, 1991, 1997; Taylor and Probst, 2008).

Tau deposition stage		Anatomic region	18F-AV-1451 PET	Diagnosis (PET)
I	Trans-entorhinal	Transentorhinal cortex, perirhinal cortex (medial temporal lobe)	Entorhinal cortex, Hippocampus, Parahippocampal cortex (Cho et al., 2016)	MCI
II		Entorhinal cortex (lamina II)
III	limbic	Hippocampus, temporal allocortex
IV		Neocortical association fields next to the hippocampus	Isocortical spreading, particular differences to MCI in the precuneus, prefrontal, temporal, and inferior parietal cortex (Cho et al., 2016)	AD
V	Isocortical	Neocortex, spreading to dorsolateral
VI		Primary sensory and motor areas

¹⁸F-AV-1451 PET, ¹⁸F-flortaucipir positron emission tomography; MCI, mild cognitive impairment.