Reagent/Resource	Reference or Source	Identifier or Catalog Number
Experimental models
p32cKO mice (αMHC‐cre)	Saito et al (2017)
p32KO MEF cells	Yagi et al (2012)
Recombinant DNA
Nmnat2	OriGene	MR204325
Nmnat3 full	GeneScript	OMu17583D
Nmnat3 transcript varient1	OriGene	RC206772
TMEM192	Addgene	104434
Antibodies
LC3A/B (D3U4C) XP® Rabbit mAb	Cell Signaling	12741
anti‐p62(SQSTM1) pAb	MBL	PM045
LAMP2 antibody [GL2A7]	abcm	ab13524
GAPDH (14C10) Rabbit mAb	Cell Signaling	2118
anti‐Phospho‐p62(SQSTM1)(Ser351) pAb	MBL	PM074
anti‐Phospho‐p62(SQSTM1)(Ser403) mAb	MBL	D343‐3
Phospho‐eIF2α (Ser51) (D9G8) XP® Rabbit mAb	Cell Signaling	3398
Phospho‐ULK1 (Ser555) (D1H4) Rabbit	Cell Signaling	5869
Phospho‐ULK1 (Ser757) (D7O6U) Rabbit mAb	Cell Signaling	14202
ULK1 (D8H5) Rabbit mAb	Cell Signaling	8054
NMNAT‐3 (D‐10) antibody	Santa Cruz	sc‐390433
MTCO1 antibody [1D6E1A8]	abcm	ab14705
Monoclonal Anti‐HA antibody produced in mouse	Sigma‐Aldrich	H3663
Anti‐HA‐tag pAb‐Alexa Fluor 488	MBL	561‐A48
DYKDDDDK Tag Monoclonal Antibody (L5), Alexa Fluor 488	ThermoFisher	MA1‐142‐A488
ANTI‐FLAG® antibody produced in rabbit	Sigma‐Aldrich	F7425
PBEF/Visfatin/NAMPT Antibody	NOVUS	NB100‐594
Hexokinase II (C64G5) Rabbit mAb	Cell Signaling	2867
Anti‐PGK1 antibody [EPR19057]	abcm	ab199438
V‐ATPase B1/2 Antibody (F‐6)	Santa Cruz	sc‐55544
Anti‐Multi Ubiquitin mAb	MBL	D058‐3
Anti‐Pyruvate dehydrogenaseE2/E3bp antibody	abcm	ab110333
Anti‐HIF‐1 alpha antibody	abcm	ab179483
Anti‐Lactate Dehydrogenase antinody	abcm	ab47010
Anti‐NMNAT2 antibody	abcm	ab56980
DAPI solution	Dojindo	D532
p32	Yagi et al (2012)
VDAC	Yagi et al (2012)
Oligonucleotides and sequence‐based reagents
PCR primers	This study	Table EV1
Chemicals, enzymes and other reagents
HIF1α inhibitor	MERCK	934593‐90‐5
DexoMAG40	Liquid Research Ltd	F2288
GAP (Glyceraldehyde 3‐phosphate)	SIGMA	G5251
ADP	SIGMA	A2754
NAD	SIGMA	N0632
FK866	Selleckchem.com	S2799
Bafilimycin A	BioViotica	NSC381866
LysoSensor™ Yellow/Blue DND‐160	Invitrogen	L7545
IA (Sodium iodoacetate)	SIGMA	I2512
DQ‐BSA	Thermo Fisher Scientific	D12050
Dextran TMR	Invitrogen	D1868
Dextran Green	Invitrogen	D7170
ACMA (9‐amino‐6‐chloro‐2‐methoxyacridine)	Invitrogen	A1324
YM201636	Cayman	13576
Concanamycin A	BioViotica	BVT‐0237
DAPRed	DOJINDO	D675
DALGreen	DOJINDO	D676