Fig 2.

Brain wide expression profiles of ANK2 and TSC2 in the mouse brain taken from in-situ hybridization data from the Allen Brain Atlas data set (http://www.brain-map.org). Sagittal sections of expression in the adult mouse (P56) brain for both (a) ANK2 and (b) TSC2. Strong expression for both genes is found in a number of brain regions, including: CTX = Cortex, HC = Hippocampus, CB = Cerebellum, MH = Medial habenula, TT = Taenia tecta. Coronal sections (c) and (d), left panels) were taken from Allen Brain Atlas in a pre-rendered to fit an annotated format (c) and (d), right panels) allowing easy identification expression in different brain regions. This was used to identify brain regions demonstrating strongest expression (e) and (f), see text for details). PA = piriform area, MA = magnocellular nucleus, EPI = epithalamus, DG = dentate gyrus, AVPV = anteroventral periventricular nucleus, OT = olfactory tubercle, PS = parastrial nucleus, TT = tenia tecta, AVP = anteroventral preoptic nucleus, STVr = Striatum, ventral region, BAC = bed nucleus of the anterior commissure, PALv = pallidum, ventral region, BST = bed nuclei of the stria terminalis, LS = lateral septal nucleus, MPN = medial preoptic nucleus, LSX = lateral septal complex, CTX = cortex, AOB = accessory olfactory bulb, PMv = ventral premammillary nucleus, TRN = tegmental reticular nucleus, PP = peripeduncular nucleus, NLOT = nucleus of the lateral olfactory tract, ARH = arcuate hypothalamic nucleus, PP = peripenducular nucleus, TR = postpiriform transition area, RHP = retrohippocampal region, PPY = Parapyramidal nucleus.