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. 2021 Apr 1;12:646903. doi: 10.3389/fphys.2021.646903

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Copyright © 2021 Wang, Xu, Niu, Fang, Guo, Chen, Zhu, Dong, Zhao, Wang, Qi, Ren, Li, Liu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpressing miR-22 aggravates cardiac dysfunction in DOXIC. (A) M-mode Echocardiograms representative image (n = 6), (B) LVEF, (C) LVFS, (D) LVESD, (E) LVEDD, (F) Representative images of Masson staining, (G) Relative collagen area, (H) Representative WGA staining images, (I) Relative cell area, (J) serum LDH (n = 6), (K) serum CK-MB (n = 6), Data were shown as mean ± SEM. *P < 0.05 vs. saline group, ^‡P < 0.05 vs. DOX group, ^†P < 0.05 vs. miR-22^cOE group. All the experiments were repeated three times.