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. 2021 Apr 1;11:644117. doi: 10.3389/fonc.2021.644117

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Copyright © 2021 Wu, Chen, Feng, Zhang, Xu, Zhang, Wu, You, Xia and Ma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LC-C induces radiosensitivity in xenograft models. A549-IR xenograft nude mice were treated with LC-C, radiation, or both. (A) Body weight of mice in four groups; (B) Graphs showing the tumor growth of A549-IR xenograft; (C) Western blotting showing change of expressions of ERRFI1 in xenograft tumors; (D) Immunohistochemical staining of ERRFI1 in xenograft tumors; (E) qRT-PCR analysis of ERRFI1 expression in xenograft tumors. Samples were run in triplicate and normalized to β-actin mRNA to determine relative expression. One datum that deviated noticeably from the group was eliminated. Results shown are the means ± standard deviation. *Significant difference at P < 0.05 level. **Significant difference at P < 0.01 level. ***Significant difference at P < 0.001 level.