TABLE 1.
Genetic associations in PsA.
| Gene | Description | Pathway | Disease association |
References | ||
| PsA | Ps | Others | ||||
| IL12B | Interleukin 12B (IL-12β) | IL-23/Th17 | x | x | IBD, RA, SLE, Behcet’s disease | Bowes et al., 2015 |
| IL23R | Interleukin 23 receptor (IL-23R) | IL-23/Th17 | x | x | IBD, RA, SLE, BD, MS | Bowes et al., 2015 |
| IL23A | Interleukin 23, alpha subunit p19 (IL-23A) | IL-23/Th17 | x | x | IBD, SLE, MS | Bowes et al., 2015 |
| STAT3 | Signal transducer and activator of transcription 3 | IL-23/Th17 | x | x | IBD, SLE, MS | Cenit et al., 2013 |
| TYK2 | Tyrosine kinase 2 | IL-23/Th17 | x | x | SLE, MS, IBD, RA | Bowes et al., 2015 |
| TRAF3IP2 | TRAF3 interacting protein 2 | x | x | RA, SLE | Bowes et al., 2015 | |
| IL2/IL21 | Interleukin 2 | IL-21 pathway | x | x | RA, MS | |
| TNIP1 | TNFAIP3 interacting protein 1 | TNF-induced NFkB-dependent gene expression | x | x | SLE, BD, | Bowes et al., 2015 |
| REL | V-rel avian reticuloendotheliosis viral oncogene homolog | Part of NFkB complex | x | x | BD | Ellinghaus et al., 2012 |
| FBXL19 | F-box and leucine-rich repeat protein 19 | Inhibits NFkB signaling | x | x | Stuart et al., 2010 | |
| IRAK | Interleukin-1 receptor-associated kinase 1 | T cell activation and cytokine signaling | x | RA, SLE, | Chatzikyriakidou et al., 2010 | |
| KIR2DL2 | Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 | NK cell activity | x | Chandran et al., 2014 | ||
| KIR2DS2 | Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 | NK cell activity | x | RA | Chandran et al., 2014 | |
| TLR2 | Toll-like receptor 2 | Microbial tolerance | x | SLE, IBD | Oliveira-Tore et al., 2019 | |
| MICA | MHC class I polypeptide-related sequence A | T cell activation and cytokine signaling | x | x | RA, IBD, SLE | Queiro et al., 2014 |
| MICB | MHC class I polypeptide-related sequence B | T cell activation and cytokine signaling | x | RA, IBD, SLE | Queiro et al., 2014 | |
| HLA-B*08 | Human Leukocyte Antigen B08 | T cell activation and cytokine signaling | x | Winchester et al., 2012 | ||
| HLA-B*27 | Human Leukocyte Antigen B27 | T cell activation and cytokine signaling | x | x | Alenius et al., 2002; Elkayam et al., 2004; Liao et al., 2008; Eder et al., 2012; Minh et al., 2019 | |
| HLA-B*38 | Human Leukocyte Antigen B38 | T cell activation and cytokine signaling | x | Eder et al., 2012; Winchester et al., 2012 | ||
| HLA-B*39 | Human Leukocyte Antigen B39 | T cell activation and cytokine signaling | x | Winchester et al., 2012 | ||
| COL10A1 | Collagen10A1 | Cartilage/bone metabolism | x | Caputo et al., 2020b | ||
| mRNA-146a | MiRNA-146a | Microbial tolerance | x | Maharaj et al., 2018 | ||
| COL6A5 | Collagen6A5 | Angiogenesis and vascular proliferation | x | Caputo et al., 2020b | ||
| COL8A1 | Collagen8A1 | Angiogenesis and vascular proliferation | x | Caputo et al., 2020b | ||
PsA, psoriatic arthritis; Ps, psoriasis; others, other autoimmune/inflammatory diseases associated with genetic variants of these genes; IBD, inflammatory bowel disease; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; BD, Behcet disease; MS, multiple sclerosis.