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. 2021 Apr 1;8:646832. doi: 10.3389/fcvm.2021.646832

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Copyright © 2021 Wan, You and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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circ_0003204 silencing alleviates ox-LDL-resulted HUVECs injury by regulating miR-942-5p. HUVECs were introduced with si-circ_0003204#1 or/and miR-942-5p inhibitor, followed by treatment with 100 mg/L ox-LDL. Cell viability (A), apoptosis (C), and the levels of PCNA and Bax (B,D) were assessed via CCK-8, flow cytometry and western blot assays. (E-G) MDA level, SOD activity and ROS formation were examined by commercial kits. (H-J) The levels of inflammatory cytokines were measured by ELISA. Data were presented as mean ± SD, n = 3. *P < 0.05, **P < 0.01, and ***P < 0.001.