Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 2;66:103315. doi: 10.1016/j.ebiom.2021.103315

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig 2 — Late PDAC is characterized by Epithelial-Mesenchymal Transition (EMT) and Cancer Stem cell (CSC) properties. (a-b) The t-SNE plots showing ductal cell subpopulations in subcluster analysis, according to clustering distribution in the a, sample source in the b. (c) Heatmap presenting the marker genes expression levels among ductal cell subpopulation. (d) Volcano plot showing the differential expression genes (DEGs) of ductal cells between PDAC I and II, red and blue dots represented the genes upregulated and downregulated respectively (PDAC II vs PDAC I). The names of top 10 up/downregulated genes were marked. (e) Venn diagram indicating the intersection between upregulated genes (PDAC II vs I) and those (PDAC III vs I). (f-g) Gene ontology analysis showing molecular function terms for genes upregulated in PDAC II and III in the f, in PDAC I in the g. (h) Violin plot demonstrating late PDAC had significantly higher expression levels of mesenchymal and cancer stem cell markers, and EPCAM (ductal cell marker) confirming their ductal cell identity.