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. 2021 Apr 1;11:620989. doi: 10.3389/fonc.2021.620989

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Copyright © 2021 Li, Lin, Wang, Wang, Yang, Mu, Chen and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heterogeneity was observed in the tumor immune microenvironment between patients with lung squamous cell carcinoma. The t-distributed stochastic neighbor embedding plots revealed heterogeneous cell distributions in the tumor (A) and adjacent (B) regions between different individuals. The immune microenvironment’s cellular components (tumor cells, immune cells, and stromal cells) varied in the tumor (C) and adjacent (D) regions between individuals. (E) There was no significant difference in T-cell infiltration between the tumor and adjacent regions. (F) More immune cells tended to infiltrate the tumor regions (rather than the adjacent regions) in smokers, relative to in non-smokers. n.s. means no significance.