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. 2021 Apr 2;66:103307. doi: 10.1016/j.ebiom.2021.103307

Fig. 4.

Fig. 4

Pharmacokinetic profile of OLZ and RISP after oral administration in rats pre-treated with the vehicle, probiotic or antibiotic. (a) Plasma levels and area under the curve (AUC) of OLZ. Following a 24 h break, OLZ (20 mg/kg) was orally administered to rats pre-treated with vehicle, probiotic or antibiotic for 14 days (n = 7/group, n = 3 @1 h timepoint). The AUC of OLZ is increased by antibiotic administration (One-way ANOVA F(2;20)=3.58, p < 0.05; t-test p = 0.033). (b) Plasma levels and AUC of RISP. Following a 24 h break, RISP (15 mg/kg) was orally administered to rats pre-treated with vehicle, probiotic or antibiotic for 14 days (n = 6–7/group). (c) Pharmacokinetic parameters of OLZ and RISP after oral administration in rats pre-treated with vehicle, probiotic or antibiotic. Each point in the PK curve represents the average of 7 independent samples (n = 7/experimental group/drug), apart from the OLZ 1.5h time-point where plasma samples were harvested only from 3 rats (n = 3). The OLZ or RISP concentration in each individual plasma sample was calculated based on the average of duplicate readings. Bar plots are expressed as mean + SEM; graphs over time are expressed as mean + SD.