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. 2021 Apr 2;66:103307. doi: 10.1016/j.ebiom.2021.103307

Table 1.

Overview of the physiochemical properties of the antipsychotics.

Drug name, IUPAC name, and structure Dosage Physiochemical properties
Mol.wt. Log P pKa Solubility (H2O)
Olanzapine
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno [2,3b] [1,5]benzodiazepineImage, table 1 		Target: 10 mg/day 312 g/mol 2 7.37a 0.039 mg/ml
Risperidone
3- [2- [4-(6-fluoro-1,2-benzoxazol-3-yl) piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-pyrido [1,2-a]pyrimidin-4-oneImage, table 1 		Range: 2–10 mg/day 410 g/mol 3.49 8.24a 0.064 mg/mlb

Log P: partition co-efficient;

a

[18];

b

[19]