Fig. 3.

Bactericidal responses. (a) S. flexneri 2a-specific geometric mean SBA endpoint titres grouped by vaccinated or placebo subjects. * = significant difference as compared to baseline titres within treatment group. Significance determined by repeated measures ANOVA of log-transformed titres with Bonferroni post-hoc test. (b) S. flexneri 2a-specific geometric mean SBA endpoint titres grouped by vaccinated subjects with or without consensus shigellosis, and placebo subjects with or without consensus shigellosis. * = significant difference as compared to baseline titres within the same treatment group/shigellosis outcome. Significance determined by repeated measures ANOVA of log-transformed titres with Bonferroni post-hoc test. (c) Percent efficacy against consensus shigellosis post-challenge in vaccinated subjects across increasing serum bactericidal titres measured at time of challenge (day 56).