Table 1.
Summary of treatment and outcome
| Case | Sex | ASO | ATO | ALRS | AET | Treatment | Outcome |
|---|---|---|---|---|---|---|---|
| 1 | M | 75 | 78 | 104 | 896 | PHB | Epilepsy remission. Died at 3920 days. Postmortem: CRD |
| 2 | M | 71 | 73 | 107 | 610 | PHB | Epilepsy remission. Phenobarbital dose 0.44 mg/kg/SID since day 373. Died at 631 days. Postmortem: CRD. |
| 3 | M | 116 | 124 | 125 | 712 | PHB | Epilepsy remission. Died at 1409 days. Postmortem: CRD |
| 4 | M | 157 | – | – | 191 | – | Died at 192 days. Postmortem: Bacterial septicaemia (Salmonella spp) |
| 5 | M | 75 | 77 | 457 | Unfinished | PHB | ES remission. Phenobarbital dose 0.6 mg/kg/SID since day 1537. Current age 3543 days |
| 6 | M | 63 | 64 | 76 | Unfinished | PHB | Died at 134 days. Postmortem: Oesophageal foreign body. |
| 7 | F | 69 | 82 | 1599 | Unfinished | PHB, IMP | Died at 2526 days. Postmortem: Cardiac insufficiency. |
| 8 | F | 62 | 66 | 87 | 452 | PHB | Epilepsy remission. Current age 2845 days. |
| 9 | F | 77 | 78 | 77 | 482 | PHB | Epilepsy remission. Current age 2835 days. |
| 10 | F | 64 | 66 | 398 | Unfinished | PHB | Died at 428 days during cluster ES. Postmortem: Multiorgan failure and DIC associated with haemorrage and oedema affecting piriform and temporal lobes bilaterally. |
| 11 | F | 64 | 65 | 66 | 99 | PHB | Epilepsy remission. Current age 2101 days. |
| 12 | M | 795 | 796 | 857 | Unfinished | PHB, IMP | ES remission. Current age 2104 days. |
| 13 | M | 74 | 75 | 140 | Unfinished | PHB | ES remission. Phenobarbital dose 0.46 mg/kg/SID since day 522. Current age 1738 days. |
| 14 | M | 67 | 68 | 68 | 1648 | PHB | Epilepsy remission. Phenobarbital dose 0.42 mg/kg/SID since day 522. Current age 1738 days. |
| 15 | F | 63 | 72 | 827 | Unfinished | PHB, IMP | Euthanasia performed at 853 days due to a severe deterioration and poor quality of live. Postmortem: no significant findings. |
| 16 | F | 65 | 71 | 900 | Unfinished | PHB, IMP | ES remission. Current age 1753 days. |
| 17 | M | 66 | 70 | 317 | Unfinished | PHB | ES remission. Current age 1398 days. |
| 18 | M | 63 | 67 | 451 | Unfinished | PHB, IMP | Died at 451 days. Postmortem: Bacterial septicaemia (Streptococcus spp) |
| 19 | M | 60 | 80 | 79 | 361 | PHB, IMP | Epilepsy remission. Imepitoin started due to an early withdrawal of phenobarbital. Current age 956 days. |
| 20 | F | 73 | 75 | 1148 | Unfinished | PHB, LVT, PGB, ZNS | Euthanasia performed at 1157 days due to a severe deterioration and poor quality of live. Postmortem: no significant findings. |
Ages in days. ASO age at seizure onset, ATO age at treatment onset (phenobarbital), ALRS Age at last reported seizure, AET age at the end of treatment, PHB Phenobarbital, IMP imepitoin, LVT levetiracetam, PGB pregabalin, ZNS zonisamide, CRD chronic renal disease, ES Epileptic Seizure, DIC Disseminated intravascular coagulation