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Feprazone reduced the expressions of p53 and p21 in IL-1β-challenged C-28/I2 chondrocytes. Cells were stimulated with IL-1β (10 ng/mL) in the presence or absence of Feprazone (20 μM). (A) mRNAs of PAI-1 and p21 and (B) proteins of PAI-1 and p21 (n = 5; ###, P < 0.001 vs the vehicle group; &, P < 0.05 vs the IL-1β group; &&, P < 0.01 vs the IL-1β group).
