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Feprazone prevented the activation of NF-κB in IL-1β-challenged C-28/I2 chondrocytes. Cells were stimulated with IL-1β (10 ng/mL) in the presence or absence of Feprazone (20 μM) for 6 h. (A). Nuclear levels of NF-κB p65 and (B) luciferase activity of NF-κB (n = 5; ###, P < 0.001 vs vehicle group; &, P < 0.05 vs IL-1β group; &&, P < 0.01 vs IL-1β group).
