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Feprazone promoted the activation of Nrf2 in IL-1β-challenged C-28/I2 chondrocytes. Cells were stimulated with IL-1β (10 ng/mL) in the presence or absence of Feprazone (20 μM) for 6 h. (A) Nuclear levels of Nrf2 and (B) intracellular ROS was measured using DCFH-DA staining. Scale bar, 100 μm (n = 4 or 5; ##, P < 0.01 vs the vehicle group; ###, P < 0.001 vs the vehicle group; &&, P < 0.01 vs the IL-1β group).
