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Silencing of Nrf2 abolished Feprazone-induced NF-κB activation and cellular senescence. Cells were transfected with Nrf2 siRNA, followed by stimulation with IL-1β (10 ng/mL) in the presence or absence of Feprazone (20 μM). (A) Western blot analysis revealed successful knockdown of Nrf2, (B) luciferase activity of NF-κB, and (C) cellular senescence (n = 5; ####, P < 0.0001 vs vehicle group; &&, P < 0.01 vs IL-1β group; $$, P < 0.01 vs IL-1β + Feprazone group).
