Flow cytometric
analysis depicting the inhibition of CHIKV envelope
E2 glycoprotein expression after treatment with the compound QVIR.
(a) Histogram analysis showing percent positive cells for envelope
E2 glycoproteins: mock + infection (INF) S27 and infection (INF) +
compound QVIR (5, 10, and 20 μM). (c) Graphical representation
showing percent positive cells for mock + infection (INF) S27 and
infection (INF) + compound QVIR (5, 10, and 20 μM). Similarly,
the expression profile of nonstructural protein nsP2 was presented
(b) as a histogram and (d) by graphical representations. Student’s t-test was performed to calculate the p values. p < 0.05 was considered to be statistically
significant between groups (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001).