Fig. 4. Compound 61 binds to αS fibrils with nM affinity. (a) Competition binding curves in αS fibrils with [3H]Tg-190b. (b) Compound 61 has an IC50 of 6.69 nM. (c) Saturation binding curves for [125I]61. Kd values were obtained for αS fibrils (b, Kd = 1.06 nM) and Aβ42 fibrils (c, Kd = 4.56 nM). Data points represent mean ± s.d. (n = 3).
