Table 2.
Thrombotic complications in 19 patients with COVID-19.
| Case | Age (years) | Sex (M/F) | Diagnosis of COVID-19 | Risk factors | Symptoms of DVT | Days A* | D-dimer top-value (ug/mL) | Days B** | Deep vein ultrasound found DVT |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 38 | F | Severe | Bed rest infection obesity | Pain swelling | 5 | 7.04 | 5 | Right fibular vein right gastrocnemius intermuscular vein |
| 2 | 68 | F | Severe | Bed rest infection | – | 15 | >8 | 16 | Right popliteal vein both fibular vein both posterior tibial vein both gastrocnemius intermuscular vein |
| 3 | 64 | F | Severe | Bed rest infection hypertension DM history of PCI | – | 6 | >8 | 12 | Both gastrocnemius intermuscular vein |
| 4 | 56 | F | Severe | Bed rest infection | – | 1 | >8 | 16 | Both gastrocnemius intermuscular vein |
| 5 | 64 | F | Severe | Bed rest infection | – | 12 | 4.08 | 19 | Both gastrocnemius intermuscular vein |
| 6 | 66 | F | Severe | Bed rest infection | – | 2 | 3.95 | 9 | Left gastrocnemius intermuscular vein |
| 7 | 62 | M | Severe | Infection | – | 1 | 1.38 | 8 | Left gastrocnemius intermuscular vein |
| 8 | 70 | F | Critical | Bed rest infection advanced age history of pulmonary malignant | – | 1 | >8 (found on day 16) | 16 | Both gastrocnemius intermuscular vein |
| 9 | 61 | M | Critical | Bed Rest Infection Obesity Hypertension | – | 7 | >8 | 7 | Right fibular vein |
| 10 | 77 | M | Critical | Bed Rest Infection Advanced Age | – | 9 | 5.42 | 20 | Both fibular vein both posterior tibial vein both gastrocnemius intermuscular vein |
| 11 | 71 | F | Critical | Bed rest infection obesity DM | – | 5 | >8 | 8 | Not performed*** |
| 12 | 55 | M | Critical | Bed rest infection | – | 5 | >8 (found on day 14) | 19 | Both gastrocnemius intermuscular vein |
| 13 | 61 | F | Critical | Bed rest infection | – | 2 | >8 | 12 | Both gastrocnemius intermuscular vein |
| 14 | 61 | M | Critical | Bed rest infection hypertension | – | 2 | >8 | 6 | Left popliteal vein left fibular vein left posterior tibial vein both gastrocnemius intermuscular vein |
| 15 | 79 | M | Critical | Bed rest infection advanced age hypertension history of DVT history of PCI history of cerebral infarctioon | – | 1 | >8 | 1 | Left popliteal vein left fibular vein left gastrocnemius intermuscular vein |
| 16 | 75 | M | Critical | Bed rest infection advanced age hypertension history of cerebral hemorrhage | – | 2 | 4.16 | 4 | Right posterior tibial vein right gastrocnemius intermuscular vein |
| 17 | 70 | M | Critical | Bed rest infection advanced age hypertension | – | 1 | >8 (found on day 12) | 8 | Both gastrocnemius intermuscular vein |
| 18 | 72 | F | Critical | Bed rest infection advanced age DM hypertension cerebral infarctioon (acute phase) | – | 2 | >8 | 7 | Right gastrocnemius intermuscular vein |
| 19 | 55 | M | Critical | Bed rest infection hypertension | – | 9 | >8 | 10 | Left posterior tibial vein both gastrocnemius intermuscular vein |
| Case | Therapeutic LMWH | Echocardiographic evaluation | CTPA (Y/N) | Outcomes | |||||
| 1 | q12h | No pulmonary hypertension | Not performed | Discharged home after 21-day hospitalization | |||||
| 2 | q12h | No pulmonary hypertension | Not performed | Discharged home after 26-day hospitalization | |||||
| 3 | qd (from dayA to dayB) q12h (after dayB) | No pulmonary hypertension | Not performed | Discharged home after 50-day hospitalization | |||||
| 4 | q12h (after dayA) | Not performed | N | Discharged home after 51-day hospitalization | |||||
| 5 | q12h (after dayB) | Not performed | Y | Discharged home after 35-day hospitalization | |||||
| 6 | qd (from dayA to dayB) q12h (after dayB) | Not performed | Not performed | Discharged home after 35-day hospitalization | |||||
| 7 | qd (from dayA to dayB) q12h (after dayB) | Not performed | Not performed | Discharged home after 17-day hospitalization | |||||
| 8 | qd (from dayA to dayB) (discontinued for bleeding and decrease of D-Dimer value from 1.28 to 0.67) (after dayB) | Mild pulmonary hypertension (found on day 21) | Not performed | Disease progress after 16-day hospitalization died after 15-day in ICU | |||||
| 9 | q12h (discontinue after 9 days for gastrointestinal bleeding) | No pulmonary hypertension | Not performed | Died after 24-day hospitalization | |||||
| 10 | qd (increase the dose after DVT were found) | No pulmonary hypertension | Not performed | Discharged home after 65-day hospitalization | |||||
| 11 | q12h (after dayB) | Not performed | Not performed | Died after 9-day hospitalization | |||||
| 12 | qd (after day14) | Not performed | Not performed | Died after 19-day hospitalization | |||||
| 13 | qd (after dayA) | Not performed | Not performed | Died after 16-day hospitalization | |||||
| 14 | qd (from dayA to dayB) q12h (after dayB) | not performed | not performed | Discharged home after 48-day hospitalization | |||||
| 15 | qd (after day 8) | No pulmonary hypertension | Not performed | Discharged home after 55-day hospitalization | |||||
| 16 | qd (from dayA to dayB) q12h (after dayB) | Not performed | Not performed | Discharged home after 40-day hospitalization | |||||
| 17 | qd (from dayB to day12) q12h (after day12) | Not performed | Not performed | Discharged home after 23-day hospitalization | |||||
| 18 | qd (after dayA) | Not performed | Not performed | Discharged home after 44-day hospitalization | |||||
| 19 | q12h (after dayB) | No pulmonary hypertension | Not performed | Discharged home after 54-day hospitalization | |||||
*
Days of hospitalization before the discovery of D-dimer value increase than normal range;
**
Days of hospitalization before thrombosis were found;
***
Thrombosis were found in femoral vein during femoral vein catheterization.
DM – diabetes mellitus; PCI – percutaneous coronary intervention; DVT – deep vein thrombosis; ICU – Intensive Care Unit; CTPA – computed tomographic pulmonary.