1. Antinuclear antibodies (ANA) – screen testb
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2. Screen test for the restricted number of specific antinuclear antibodies (ANA): specify included antigensc
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3. ENA screen test: specify included antigensd
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Tests for specific antibodiesa
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1. Antibodies to double-stranded DNA (anti-dsDNA) |
2. Antibodies to SS-A (Ro) antigen (anti-SS-A (Ro))e
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3. Antibodies to SS-A (Ro60) antigen (anti-SS-A (Ro60)) |
4. Antibodies to Ro52 antigen (anti-Ro52) |
5. Antibodies to SS-B (La) antigen (anti-SS-B (La)) |
6. Antibodies to Smith antigen (anti-Sm)e
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7. Antibodies to RNP antigen (anti-RNP)f
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8. Antibodies to Topoisomerase I (anti-Topo I/Scl70) |
9. Antibodies to Jo-1 antigen (anti-Jo-1) |
10. Antibodies to centromere protein B (anti-CENP B) |
11. Antibodies to PM/Scl antigen (anti-PM/Scl) |
12. Antibodies to proliferating cell nuclear antigen (anti-PCNA) |
13. Antibodies to ribosomal P protein (anti-ribosomal P) |
14. Antibodies to histones |
15. Antibodies to nucleosomes |
16. Antibodies to RNA-polymerase III (anti-RNA-Pol III) |
17. Antibodies to DFS70 antigen (anti-DFS70) |
aMethod should be specified either along with the test name or in the legend of the report. bRefers exclusively on IIF test on HEp-2 or HEp-2000 substrate. cRefers to solid-based screen tests commercially available under the common name CTD-screen. dENA screen test refers exclusively on test comprising following antigens: SS-A (Ro) (when there is no distinction between Ro52 and Ro 60) or SS-A (Ro60) and Ro52 (TRIM21), separately; SS-B (La); Sm (or SmD according to manufacturer specification); RNP (U1-RNP or Sm/RNP, according to manufacturer specification); Scl-70 (Topo-1) and Jo-1. In the case that the screen test includes additional antigens that are not included in ENA term, use the nomenclature given under number 2. eSS-A (Ro) – if there is no distinction between Ro52 and Ro60; e Alternatively, anti-SmD in the case that manufacturer declares specificity exclusively for SmD antigen. fanti-RNP term comprises both anti-U1-RNP and anti-Sm/RNP. IIF – indirect immunofluorescence. HEp-2 – human laryngeal epidermoid carcinoma cell line type 2 substrate. CTD – connective tissue diseases. ENA – extractable nuclear antigens. RNP – ribonucleoprotein complex. |