Table 1. Subject Demographic Characteristics.
| Characteristic | No. (%)a | ||
|---|---|---|---|
| NP202 (n = 73) | Placebo (n = 74) | Overall (n = 147) | |
| Age, mean (SD), y | 56 (12) | 59 (10) | 58 (11) |
| Age categories, y | |||
| <65 | 53 (73) | 50 (68) | 103 (70) |
| 65-74 | 16 (22) | 23 (31) | 39 (27) |
| 75-84 | 3 (4) | 1 (1) | 4 (3) |
| ≥85 | 1 (1) | 0 | 1 (1) |
| Sex | |||
| Female | 6 (8) | 12 (16) | 18 (12) |
| Male | 67 (92) | 62 (84) | 129 (88) |
| Race/ethnicity | |||
| Asian | 0 | 4 (5) | 4 (3) |
| Black or African American | 0 | 4 (5) | 4 (3) |
| White | 67 (92) | 63 (85) | 130 (88) |
| Other | 5 (7) | 3 (4) | 7 (5) |
| Multiple | 1 (1) | 0 | 1 (1) |
| Weight, mean (SD), kg | 97 (24) | 89 (17) | 93 (21) |
| Height, mean (SD), cm | 176 (9) | 173 (8) | 175 (9) |
| BSA, mean (SD), m2 | 2.16 (0.29) | 2.06 (0.23) | 2.11 (0.27) |
| BMI, mean (SD) | 31 (7) | 30 (4) | 30 (6) |
| Country | |||
| Australia | 28 (38) | 32 (43) | 60 (41) |
| New Zealand | 11 (15) | 7 (10) | 18 (12) |
| United States | 34 (47) | 35 (47) | 69 (47) |
| Time from onset of symptoms to NP202 treatment, mean (SD), d | 4.9 (1.1) | 5.0 (1.0) | 4.9 (1.1) |
| No. | 66 | 71 | 137 |
| Time from hospital presentation to NP202 treatment, mean (SD), d | 4.7 (1.1) | 4.8 (1.1) | 4.8 (1.1) |
| No. | 66 | 71 | 137 |
| PCI | |||
| No. | 73 | 74 | 147 |
| Door-to-balloon time, mean (SD), h | 2.6 (6.4) | 2.7 (5.5) | 2.6 (5.9) |
| TIMI flow post-PCI | |||
| 0 | 2 (2.7) | 0 | 2 (1.4) |
| 1 | 0 | 2 (2.7) | 2 (1.4) |
| 2 | 2 (3) | 3 (4) | 5 (3) |
| 3 | 69 (95) | 69 (93) | 138 (94) |
| Location of culprit lesion | |||
| LAD proximal | 60 (82) | 62 (84) | 122 (83) |
| LAD distal | 4 (6) | 9 (12) | 13 (9) |
| LAD mid | 9 (12) | 3 (4) | 12 (8) |
| Culprit lesion stented | |||
| Yes | 73 (100) | 73 (99) | 146 (99) |
| No | 0 | 1 (1) | 1 (1) |
| Other stenosis | |||
| Yes, at least one was stented | 10 (14) | 18 (24) | 28 (19) |
| Yes, none were stented | 31 (43) | 30 (41) | 61 (42) |
| No | 32 (44) | 26 (35) | 58 (40) |
| Killip statusb | |||
| I | 63 (90) | 62 (86) | 125 (88) |
| II | 7 (10) | 9 (13) | 16 (11) |
| III | 0 | 1 (1) | 1 (1) |
| Missing | 3 | 2 | 5 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); BSA, body surface area; LAD, left anterior descending coronary artery; PCI, percutaneous coronary intervention; TIMI, thrombolysis in myocardial infarction.
Data are presented as No. (%) unless otherwise stated.
Killip class I includes individuals with no clinical signs of heart failure. Class II includes individuals with rales, an S3 gallop, and elevated jugular venous pressure. Class III describes individuals with frank acute pulmonary edema. Class IV describes individuals in cardiogenic shock or with hypotension (ie, systolic blood pressure <90 mm Hg) and evidence of peripheral vasoconstriction (ie, oliguria, cyanosis, or sweating).