Table 3. TXA and Bleeding Mortality.

Medical discipline	No. of included studies	TXA		Control		Model	Risk difference (95% CI)	P value	I2, %
		Events	No. of included patients	Events	No. of included patients
Cardiothoracic	12	0	543	1	478	Fixed effect	−0.002 (−0.016 to −0.012)	.77	0
						Random effects	−0.004 (−0.012 to 0.011)	.94
Neurological	8	43	685	91	678	Fixed effect	−0.071 (−0.102 to −0.041)	<.001	60
						Random effects	−0.056 (−0.11 to −0.002)	.04
Gynecological	8	155	10 871	191	10 814	Fixed effect	−0.003 (−0.007 to −0.000)	.05	0
						Random effects	−0.002 (−0.005 to 0.001)	.12
Orthopedic	13	0	647	0	461	Fixed effect	0.000 (−0.014 to 0.014)	.77	0
						Random effects	0.000 (−0.013 to 0.013)	>.99
Major trauma	1	489	10 060	574	10 067	Fixed effect	−0.008 (−0.015 to −0.002)	.01	NA
						Random effects	−0.008 (−0.015 to −0.002)	.01
Pediatric	1	0	40	0	42	Fixed effect	0.000 (−0.046 to 0.046)	>.99	NA
						Random effects	0.000 (−0.046 to 0.046)	>.99
Other	6	5	655	17	661	Fixed effect	−0.018 (−0.033 to −0.004)	.02	53
						Random effects	−0.01 (−0.028 to −0.009)	.30
Total	49	692	23 501	874	23 201	Fixed effect	−0.008 (−0.011 to −0.005)	<.001	9
						Random effects	−0.004 (−0.008 to −0.001)	.02

Abbreviations: NA, not applicable; TXA, tranexamic acid.