Table 3.
Estimated Risk of Mortality and Early Mortality by Diabetes Subtype (New or Known) Among a Prospective Tuberculosis Cohort in Pune, India
| Univariable Analysis | Multivariable Analysisa | ||||
|---|---|---|---|---|---|
| Outcome | Rate (95% CI) | HR (95% CI) | P Value | aHR (95% CI) | P Value |
| All-cause mortality | |||||
| TB only (n = 574) | 6.5 (4.7–8.8) | Ref | Ref | ||
| TB-DM (n = 225) | 9.9 (6.3–14.9) | 1.55 (0.9–2.59) | .09 | 1.54 (0.85–2.79) | .16 |
| New DM (n = 70) | 13.5 (7.0–25.8) | 2.13 (1.04–4.36) | .04 | 1.73 (0.80–3.76) | .17 |
| Known DM (n = 155) | 8.5 (5.0–14.4) | 1.33 (0.72–2.43) | .36 | 1.41 (0.70–2.88) | .34 |
| DM on metformin (n = 117) | 6.22 (3.11–12.43) | 0.96 (0.45–2.05) | .92 | 0.96 (0.40–2.31) | .93 |
| DM no metformin (n = 108) | 14.57 (8.78–24.17) | 2.32 (1.28–4.19) | .005 | 1.99 (1.05–3.78) | .04 |
| Early mortalityb | |||||
| TB only (n = 574) | 3.4 (1.6–6.5) | Ref | Ref | ||
| TB-DM (n = 225) | 17.5 (10.2–28.0) | 5.06 (2.26–11.35) | <.001 | 4.36 (1.62–11.76) | .004 |
| New DM (n = 70) | 24.7 (10.0–51.0) | 7.17 (2.67–19.27) | <.001 | 6.56 (2.18–19.71) | .001 |
| Known DM (n = 155) | 14.53 (6.9–26.7) | 4.20 (1.70–10.33) | .002 | 3.14 (1.03–9.61) | .045 |
| DM on metformin (n = 117) | 11.37 (4.17–24.75) | 3.30 (1.18–9.28) | .02 | 2.32 (0.67–8.08) | .20 |
| DM no metformin (n = 108) | 24.82 (12.39–44.41) | 7.13 (2.96–17.21) | <.001 | 6.17 (2.24–17.04) | <.001 |
| Post-ATT mortalityc | |||||
| TB only (n = 487) | 8.6 (5.9–12.1) | Ref | Ref | ||
| TB-DM (n = 176) | 4.5 (1.6–9.7) | 0.54 (0.22–1.28) | .16 | 0.58 (0.22–1.51) | .27 |
| New DM (n = 49) | 5.3 (0.6–19.1) | 0.64 (0.15–2.69) | .55 | 0.42 (0.10–1.6) | .25 |
| Known DM (n = 126) | 4.2 (1.1–10.7) | 0.50 (0.18–1.41) | .19 | 0.72 (0.23–2.22) | .57 |
| DM on metformin (n = 98) | 2.6 (0.3–9.5) | 0.31 (0.07–1.29) | .11 | 0.47 (0.10–2.17) | .33 |
| DM no metformin (n = 78) | 6.8 (1.9–17.5) | 0.84 (0.30–2.39) | .75 | 0.65 (0.22–1.96) | .45 |
Abbreviations: aHR, adjusted hazards ratio; ATT, antituberculosis treatment; DM, diabetes mellitus; HR, hazards ratio; TB, tuberculosis.
aAdjusted for sex, age, household income, smoking, alcohol, body mass index, daily vs intermittent TB regimen, and smear grade.
bDefined as death during the 6 months of TB treatment.
cParticipants who died on ATT or were lost to follow-up before treatment completion (before 6 months) were not included in this analysis.